Sjögren’s Syndrome (SS) is an inflammatory disease affecting moisture producing glands and leading to severe dryness of the mouth, eyes and vagina. Many patients experience profound fatigue and the disease may also impact other body systems such as the joints, lungs and nerves. It affects up to 0.4% of the population, most commonly women. Current treatment approaches are mainly focussed around artificial tears and saliva, with the latter in particular often being of limited benefit. There are no approved systemic therapies to treat the underlying immune dysregulation in SS. We are currently collaborating with a number of industry partners to develop new treatments for this under-recognised and neglected disease.